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At Ziauddin College of Medicine a student is identified as an adult learner and is expected to utilise inborn capabilities to adapt and understand the rapidly changing academic atmosphere around the world.

Academic schedule for the MBBS degree programme, reflects the innovative system-based course. The first three years of training are divided into semesters and each year comprises of two semesters. For the clinical training and experience the students are rotated through all three hospitals affiliated with the University.

Ziauddin College of Medicine has taken an initiative of improving quality of medical education by fostering adult learning styles, catering to the requirements of the students and early introduction of clinical experience. In order to facilitate student learning, the basic medical sciences curriculum utilises multiple instructional and assessment strategies.

The course content is presented with a Body System based Modular approach which ,is in line with regulations of the Pakistan Medical and Dental Council for MBBS degree. Emphasis is given to the development of conceptual understanding and the ability to construct knowledge for oneself. The students are actively involved in their learning process and assessment involves examining the learner's entire conceptual network, not just focusing on discreet facts and principles.

Curriculum reviews are taken place critically on regular basis to incorporate content updates in the form of themes for quality improvement purposes. Patient Safety is one of these integrated themes introduced in MBBS curriculum.

Faculty from Basic Health Sciences (BHS), Community Health Sciences (CHS) and Clinical Sciences are collaboratively engaged in teaching programmes. As a result, students develop a comprehensive understanding and holistic approach to recognise and solve healthcare problems.

The primary health care programme run by the university (PHC) serves as educational site for community based training. The PHC programme is a unique prototype of partnership between academia, local NGOs, government and international NGOs for education, research and service.